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Dear list!
I have clinical sample of 420 female patients I want to follow up in some
national registers after an approximately 20 year period. As a comparison
group I have a randomly drawn sample matched on age at admission for the
patient, place of residence, civil status (married, unmarried,
divorced,widowed), educational level and socioeconomic status. For each
patient I have 5 controls matched on the above criteria.
I remember from my statistics courses (years ago) that you gained
significantly more power (assuming a correlation between the matched
variables and an outcome variable) using a significance tests for matched
pairs. My questions are:
1. Is there any analysis model when you have 5 matched controls for every
patient?
2. Would I be terribly wrong in treating the patient group and the control
group as independent using for example t-test other statistics for
independent groups? This seem to me simpler but is it correct?
best
Staffan Lindberg
National Institute of Public Health
Sweden
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