Logistic Regression / Discriminant Analysis

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Logistic Regression / Discriminant Analysis

KEVIN MANNING
Dear all,

     Here is my dilemma:

I have 2 groups of participants, disease and no disease, and one continuous variable.

I want to determine a cut-off score for the variable that produces the best sensitivity and specificity.  How can I do this?

I was under the impression this could be accomplished using logistic regression, but I cannot figure it out  (I would also like to view the odds ratios that are produced as well).   ROC curves were equally confusing.

Any help at all would be most appreciated.  Thanks!!!

Kevin
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Re: Logistic Regression / Discriminant Analysis

Spousta Jan
Hi Kevin,

You should proceed with the ROC curve, I think. An example:

GET
  FILE='C:\Program Files\SPSS\Coronary artery data.sav'.
ROC
  time  BY group (1)
  /PLOT = CURVE(REFERENCE)
  /PRINT = COORDINATES
  /CRITERIA = CUTOFF(INCLUDE) TESTPOS(LARGE) DISTRIBUTION(FREE) CI(95)
  /MISSING = EXCLUDE .

In the real cases, it is not possible to get both best sensitivity and
best specificity at the same time, but you are able to find a reasonable
compromise between the two given the ROC data. If you are able to figure
out the "prices" of errors of I and II types, and the prior probability
of the disease among tested persons, you can calculate the optimal
cut-off quite exactly.

Hope this helps

Jan

-----Original Message-----
From: SPSSX(r) Discussion [mailto:[hidden email]] On Behalf Of
KEVIN MANNING
Sent: Friday, January 19, 2007 10:40 PM
To: [hidden email]
Subject: Logistic Regression / Discriminant Analysis

Dear all,

     Here is my dilemma:

I have 2 groups of participants, disease and no disease, and one
continuous variable.

I want to determine a cut-off score for the variable that produces the
best sensitivity and specificity.  How can I do this?

I was under the impression this could be accomplished using logistic
regression, but I cannot figure it out  (I would also like to view the
odds ratios that are produced as well).   ROC curves were equally
confusing.

Any help at all would be most appreciated.  Thanks!!!

Kevin