ORs and t-test for the matched sample

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ORs and t-test for the matched sample

H-19
Dear List,

Some of you already heard a bit of my data. and thanks for all the
comments.
I do still have slights problems though. i end up having large CIs with
big ORs.

for a summary:
I have a dataset of 1000 controls, 330 patients which are matched by age
and sex; end up with 162 pairs.
i have 683 variables.

i took out the variables that has a prevalance of less than 5%.
and tried to do mcNemar, and corrected with FDR. (adjusted p-values)

Q1) is it usual when one takes the significance level of p <.001( since i
have so many variables)

Q2) from my clinical experience i know that it is true to have these high!
ORs but what does it tell statisticaly?

many thanks,
H

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