Question about nesting group membership in ANOVA

[KEVIN MANNING]

Dear list-mates,

      I would greatly appreciate help with this problem.  I have 5 groups:  healthy adults, and 4 groups of cognitively impaired participants.  The impaired participants are amnestic and non-amnestic.  Within these two groups, they are impaired in either a single domain of cognition or a mutiple domain.  So I have something like this:

Groups:

Normals                  Amnestics                                                            Non-Amnestics
                               (Single, Mutiple Impairments)                            (Single, Multiple Impairments)

I would like to run an analysis of variance of a cognitive test and compare normals, amnestics, and non-amnestics, in addition to determining the effects of being either impaired in a single or mutiple domain of cognition.

Can someone help me with this?  Thanks!

Kevin Manning

[Swank, Paul R]

What I have done with such designs is to run a one way ANOVA on the five
groups but include 4 contrasts:

contrast                HA              AS              AM
NS              NM
Impaired vs not 4               -1              -1              -1
-1
Amn vs Non amn  0               -1              -1               1
1
Single vs Mult. 0                1              -1               1
-1
interaction of
AMN by domain   0               -1               1               1
-1

These are orthogonal. Additional paired comparsions (say of each
ompaired group with Normals) can be done with appropriate correction for
type 1 error.

Paul R. Swank, Ph.D. Professor
Director of Reseach
Children's Learning Institute
University of Texas Health Science Center-Houston

-----Original Message-----
From: SPSSX(r) Discussion [mailto:[hidden email]] On Behalf Of
KEVIN MANNING
Sent: Thursday, April 19, 2007 3:59 PM
To: [hidden email]
Subject: Question about nesting group membership in ANOVA

Dear list-mates,

      I would greatly appreciate help with this problem.  I have 5
groups:  healthy adults, and 4 groups of cognitively impaired
participants.  The impaired participants are amnestic and non-amnestic.
Within these two groups, they are impaired in either a single domain of
cognition or a mutiple domain.  So I have something like this:

Groups:

Normals                  Amnestics
Non-Amnestics
                               (Single, Mutiple Impairments)
(Single, Multiple Impairments)

I would like to run an analysis of variance of a cognitive test and
compare normals, amnestics, and non-amnestics, in addition to
determining the effects of being either impaired in a single or mutiple
domain of cognition.

Can someone help me with this?  Thanks!

Kevin Manning