Repeated Measures

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Repeated Measures

Gerónimo Maldonado

Hi Guys:
 
I'm really stumped trying to RUN a repeated -measures model in an experiment. Here's the descriptive:
 
Hamsters feeded on a daily basis for over a week.
4 different Rx, each one with 4 different concentration in mg.
N for each Rx/concentration = 4
Outcome: Change in Glucose Level
 
Here's the syntax:
 

GLM

week_1 week2 week_3 week_4 week_5_ week6 week_7 week_8 week_9 week_10 BY Rx

/WSFACTOR = week 10 Polynomial

/METHOD = SSTYPE(3)

/POSTHOC = Rx ( TUKEY BONFERRONI T2 )

/PLOT = PROFILE( Rx week*Rx )

/EMMEANS = TABLES(Rx) COMPARE ADJ(BONFERRONI)

/PRINT = DESCRIPTIVE OPOWER HOMOGENEITY

/CRITERIA = ALPHA(.05)

/WSDESIGN = week

/DESIGN = Rx .

 
There's the problem: Output came empty, no univariate or multivariate results, no mauchly's test...
 
Any help would be appreciated!
 

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Re: Repeated Measures

Maguin, Eugene
Geronimo,
 
I don't understand your design. You say you '4 different Rx, each one with 4 different concentration in mg.' Do you mean that the treatment consists of 4 difference concentrations of X?  Or, do you mean something else? You say 'Hamsters feeded (fed) on a daily basis for over a week.' Your hamsters probably appreciated being fed on a daily basis! Snarky comment aside, did you have one group of hamsters that received one at a time all of the different concentrations of X or did you have four (or some other number) groups of hamsters and each group received just one of the concentrations of X? By the way, how many hamsters did you have in each group and how many did you have in total?
 
Gene Maguin
 


From: SPSSX(r) Discussion [mailto:[hidden email]] On Behalf Of Gerónimo Maldonado
Sent: Monday, February 14, 2011 10:54 AM
To: [hidden email]
Subject: Repeated Measures


Hi Guys:
 
I'm really stumped trying to RUN a repeated -measures model in an experiment. Here's the descriptive:
 
Hamsters feeded on a daily basis for over a week.
4 different Rx, each one with 4 different concentration in mg.
N for each Rx/concentration = 4
Outcome: Change in Glucose Level
 
Here's the syntax:
 

GLM

week_1 week2 week_3 week_4 week_5_ week6 week_7 week_8 week_9 week_10 BY Rx

/WSFACTOR = week 10 Polynomial

/METHOD = SSTYPE(3)

/POSTHOC = Rx ( TUKEY BONFERRONI T2 )

/PLOT = PROFILE( Rx week*Rx )

/EMMEANS = TABLES(Rx) COMPARE ADJ(BONFERRONI)

/PRINT = DESCRIPTIVE OPOWER HOMOGENEITY

/CRITERIA = ALPHA(.05)

/WSDESIGN = week

/DESIGN = Rx .

 
There's the problem: Output came empty, no univariate or multivariate results, no mauchly's test...
 
Any help would be appreciated!
 

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Re: Repeated Measures

Gerónimo Maldonado


Hi Gene:
 
Sorry for the orthographic monstrosity... yes my design consists in 4 treatments:
 
* X
* Y
* Z
* A
 
Each contains 4 concentration
 
* X (5mg)
* X (10mg)
* X (15mg)
* X(20mg)... and so forth with each one of the treatments.
 
The outcome of the experiment is know which Rx @ what concentration is better in reducing C6H12O6 in mice
 
Thanks for any input!
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Re: Repeated Measures

Mike
I've appended your first post below to point out why there is confusion
over your design.  Let me make the following points:

(1) You say you have 4 treatments and 4 concentrations which would
suggest you have a 2-way completely within-subject design where every
subject (hamster) is measured 16 times (i.e., 4 x 4 = 16 combinations
or treatments and concentrations).  So, there should 16 variables specified
as containing the dep var (glucose level).  So, we expect to Tx1Con1,
Tx1Con2, Tx1Con3, Tx1Con4, Tx2Con1, ... Tx4Con4.  This
assuming that you used a full factorial design for the 4x4 within-subject
factors.

(2) In your syntax below you have "week" instead of treatment combination
and "Rx" which is specified as a between-subjects factor.  Did you have
different groups of subjects/hamster receive different treatments or was
there one group that received the 16 combination I specify in (1) above?
What exactly is "week" supposed to represent?  Why is there only 10 weeks?
You don't even mention week in your follow-up post.

More info is required.

-Mike Palij
New York University
[hidden email]



-------------------First Post--------------------
Hi Guys:

I'm really stumped trying to RUN a repeated -measures model in an experiment. Here's the descriptive:

Hamsters feeded on a daily basis for over a week.
4 different Rx, each one with 4 different concentration in mg.
N for each Rx/concentration = 4
Outcome: Change in Glucose Level

Here's the syntax:

GLM
week_1 week2 week_3 week_4 week_5_ week6 week_7 week_8 week_9 week_10 BY Rx
/WSFACTOR = week 10 Polynomial
/METHOD = SSTYPE(3)
/POSTHOC = Rx ( TUKEY BONFERRONI T2 )
/PLOT = PROFILE( Rx week*Rx )
/EMMEANS = TABLES(Rx) COMPARE ADJ(BONFERRONI)
/PRINT = DESCRIPTIVE OPOWER HOMOGENEITY
/CRITERIA = ALPHA(.05)
/WSDESIGN = week
/DESIGN = Rx .

There's the problem: Output came empty, no univariate or multivariate results, no mauchly's test...

Any help would be appreciated!


--

----- Original Message -----
From: Gerónimo Maldonado
To: [hidden email]
Sent: Monday, February 14, 2011 6:29 PM
Subject: Re: Repeated Measures

Hi Gene:

Sorry for the orthographic monstrosity... yes my design consists in 4 treatments:

* X
* Y
* Z
* A

Each contains 4 concentration

* X (5mg)
* X (10mg)
* X (15mg)
* X(20mg)... and so forth with each one of the treatments.

The outcome of the experiment is know which Rx @ what concentration is better in reducing C6H12O6 in mice

Thanks for any input!

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