Time dependent Cox Regression with multiple values for time dependent covariate

[Marco P.]

Dear All,

I'm Marco, a researcher from Italy.

I'm working on a Cox regression analysis, investigating the role of a
continuous covariate (a functional test score). I got 6 measurements for the
covariate throughout the observation period (5 years) on each subject. I was
wondering if the time dependent cox regression would be the best approach to
take account of the changing value. Do you this is correct?

If yes, how I should manage the 6 values to build the T_COV_ covariate?
Also, how should I manage the 6 measurements while computing the Cox model?

I hope someone is able to help in some way. In the case you would need more
details, please ask.

Kind regards
Marco



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[Bruce Weaver]

What is your outcome variable?  Cox regression would only be an option if the
DV is time-to-event.  


Marco P. wrote

> Dear All,
>
> I'm Marco, a researcher from Italy.
>
> I'm working on a Cox regression analysis, investigating the role of a
> continuous covariate (a functional test score). I got 6 measurements for
> the
> covariate throughout the observation period (5 years) on each subject. I
> was
> wondering if the time dependent cox regression would be the best approach
> to
> take account of the changing value. Do you this is correct?
>
> If yes, how I should manage the 6 values to build the T_COV_ covariate?
> Also, how should I manage the 6 measurements while computing the Cox
> model?
>
> I hope someone is able to help in some way. In the case you would need
> more
> details, please ask.
>
> Kind regards
> Marco
>
>
>
> --
> Sent from: http://spssx-discussion.1045642.n5.nabble.com/
>
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[Marco P.]

Yes, clearly it is.

I’m investigating the relationship with clinical outcomes (i.e. stroke, bleeding, CV Death, etc).

MP

Il giorno dom 5 ago 2018 alle 15:41 Bruce Weaver <[hidden email]> ha scritto:

What is your outcome variable?  Cox regression would only be an option if the
DV is time-to-event. 


Marco P. wrote
> Dear All,
>
> I'm Marco, a researcher from Italy.
>
> I'm working on a Cox regression analysis, investigating the role of a
> continuous covariate (a functional test score). I got 6 measurements for
> the
> covariate throughout the observation period (5 years) on each subject. I
> was
> wondering if the time dependent cox regression would be the best approach
> to
> take account of the changing value. Do you this is correct?
>
> If yes, how I should manage the 6 values to build the T_COV_ covariate?
> Also, how should I manage the 6 measurements while computing the Cox
> model?
>
> I hope someone is able to help in some way. In the case you would need
> more
> details, please ask.
>
> Kind regards
> Marco
>
>
>
> --
> Sent from: http://spssx-discussion.1045642.n5.nabble.com/
>
> =====================
> To manage your subscription to SPSSX-L, send a message to

> LISTSERV@.UGA

>  (not to SPSSX-L), with no body text except the
> command. To leave the list, send the command
> SIGNOFF SPSSX-L
> For a list of commands to manage subscriptions, send the command
> INFO REFCARD





-----
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Bruce Weaver
[hidden email]
http://sites.google.com/a/lakeheadu.ca/bweaver/

"When all else fails, RTFM."

NOTE: My Hotmail account is not monitored regularly.
To send me an e-mail, please use the address shown above.

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[David Marso]

Please provide a more complete description of your data and
Have you don,e reading in the FM about TIME PROGRAM?
What have you tried so far?
I haven't used COXREG in ages but throwing this out as a possible fish.
Consider:

TIME PROGRAM.
COMPUTE TVcov
=SUM(RANGE(T_,val1,val2)*cov1,RANGE(T_,val2,val3)*cov2,......RANGE(T_,val5,val6)*cov5).
COXREG blah blah blah....
Unless I completely misparsed your intentions.
___________________


Marco P. wrote

> Dear All,
>
> I'm Marco, a researcher from Italy.
>
> I'm working on a Cox regression analysis, investigating the role of a
> continuous covariate (a functional test score). I got 6 measurements for
> the
> covariate throughout the observation period (5 years) on each subject. I
> was
> wondering if the time dependent cox regression would be the best approach
> to
> take account of the changing value. Do you this is correct?
>
> If yes, how I should manage the 6 values to build the T_COV_ covariate?
> Also, how should I manage the 6 measurements while computing the Cox
> model?
>
> I hope someone is able to help in some way. In the case you would need
> more
> details, please ask.
>
> Kind regards
> Marco
>
>
>
> --
> Sent from: http://spssx-discussion.1045642.n5.nabble.com/
>
> =====================
> To manage your subscription to SPSSX-L, send a message to

> LISTSERV@.UGA

>  (not to SPSSX-L), with no body text except the
> command. To leave the list, send the command
> SIGNOFF SPSSX-L
> For a list of commands to manage subscriptions, send the command
> INFO REFCARD

Q



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