how to test inferiority in SPSS

[Lunfrankie]

I would like to test for non-inferiority in SPSS. Would anyone know how to test non-inferiority in SPSS?
Do I need to buy the expansion for SPSS for it?
Please kindly tell me how to do so, thank you very much.

[Maguin, Eugene]

Please define non-inferiority.
Gene Maguin

-----Original Message-----
From: SPSSX(r) Discussion [mailto:[hidden email]] On Behalf Of
Lunfrankie
Sent: Thursday, December 29, 2011 9:40 PM
To: [hidden email]
Subject: how to test inferiority in SPSS

I would like to test for non-inferiority in SPSS. Would anyone know how to
test non-inferiority in SPSS?
Do I need to buy the expansion for SPSS for it?
Please kindly tell me how to do so, thank you very much.

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[la volta statistics]

Hi

SPSS does not have tests for non-inferiority implemented. However, it
is easy to do it yourself, calculating the Ci's and p-values using
formulas you will find on the web. This is, of course,  depending on
what kind of test you plan to do (e.g. comparing categorical data,
comparing continuous data etc.). You always need to have a
non-inferiority margin, defining what would be accepted as 'no
difference'. Normally non-inferiority is established with the CI's

Look up for example: Blackwelder WC. Proving the null hypothesis.
Controlled Clinical Trials 1982; 3:345–353.
or:
http://www.sctweb.org/presentations/2008/DesignandConcept.pdf

Hope this helps, Christian

**********************************
la volta statistics
Christian Schmidhauser, Dr.phil.II
Weinbergstrasse 108
CH-8006 Zürich
Tel: [phone]
Fax: [phone]
email: mailto:[hidden email]
Web: www.lavolta.ch





On Fri, 30 Dec 2011 09:08:12 -0500
  Gene Maguin <[hidden email]> wrote:

> Please define non-inferiority.
> Gene Maguin
>
> -----Original Message-----
>From: SPSSX(r) Discussion [mailto:[hidden email]] On Behalf
>Of
> Lunfrankie
> Sent: Thursday, December 29, 2011 9:40 PM
> To: [hidden email]
> Subject: how to test inferiority in SPSS
>
> I would like to test for non-inferiority in SPSS. Would anyone know
>how to
> test non-inferiority in SPSS?
> Do I need to buy the expansion for SPSS for it?
> Please kindly tell me how to do so, thank you very much.
>
> --
> View this message in context:
> http://spssx-discussion.1045642.n5.nabble.com/how-to-test-inferiority-in-SPS
> S-tp5109102p5109102.html
> Sent from the SPSSX Discussion mailing list archive at Nabble.com.
>
> =====================
> To manage your subscription to SPSSX-L, send a message to
> [hidden email] (not to SPSSX-L), with no body text except
>the
> command. To leave the list, send the command
> SIGNOFF SPSSX-L
>For a list of commands to manage subscriptions, send the command
> INFO REFCARD
>
> =====================
> To manage your subscription to SPSSX-L, send a message to
> [hidden email] (not to SPSSX-L), with no body text except
>the
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> INFO REFCARD

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[statisticsdoc]

SPSS does not contain a module specifically for testing non-inferiority.
The statistics that you need to carry out these computations by hand can be
obtained from the descriptive procedure (for interval data) or from
frequencies (for categorical data).  The logic of the procedure requires
that you establish a range of differences (or ratios) in treatment outcomes
that is clinically insignificant - that is a clinical issue rather than a
statistical one.  Having established a range of indifference, you will need
to compute the confidence interval for the treatment effect in your data.
To support a claim of non-inferiority, the confidence interval must fall
within the specified range of clinical indifference.

You may find the following book helpful.  It provides a comprehensive
treatment of the subject in understandable terms.

Stefan Wellek (2010). Testing statistical hypotheses of equivalence, 2nd
Edition.  Chapman and Hall.

Best,

Stephen Brand

www.StatisticsDoc.com


-----Original Message-----
From: SPSSX(r) Discussion [mailto:[hidden email]] On Behalf Of
Lunfrankie
Sent: Thursday, December 29, 2011 9:40 PM
To: [hidden email]
Subject: how to test inferiority in SPSS

I would like to test for non-inferiority in SPSS. Would anyone know how to
test non-inferiority in SPSS?
Do I need to buy the expansion for SPSS for it?
Please kindly tell me how to do so, thank you very much.

--
View this message in context:
http://spssx-discussion.1045642.n5.nabble.com/how-to-test-inferiority-in-SPS
S-tp5109102p5109102.html
Sent from the SPSSX Discussion mailing list archive at Nabble.com.

=====================
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=====================
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=====================
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[Rich Ulrich]

I'm pleased to see that the regulators have reached some
apparent consensus on how to test for equivalence -- The
approaches were fairly ad-hoc, back 10 years ago, when I
tried to figure out what to advise someone in a Usenet sci.stat.*
group.  Today, Wiki separately outlines what regulators want
in Australia, the U.S., and Europe; and the requirements look
pretty similar. 

Wellek's book is the top citation today in Google Scholar - but
using Google Scholar is trickier than it used to be, since Scholar
is no longer a listed choice.  Putting scholar.google.com  in the
address field worked for me.  Searching for < bioequivalence >
returned a different selection of citations, which might also
be useful.  But nothing before about 2003 will give *requirements*
since those were still in flux.

--
Rich Ulrich

> Date: Sat, 31 Dec 2011 08:52:59 -0500

> From: [hidden email]
> Subject: Re: how to test inferiority in SPSS
> To: [hidden email]
>
> SPSS does not contain a module specifically for testing non-inferiority.
> The statistics that you need to carry out these computations by hand can be
> obtained from the descriptive procedure (for interval data) or from
> frequencies (for categorical data). The logic of the procedure requires
> that you establish a range of differences (or ratios) in treatment outcomes
> that is clinically insignificant - that is a clinical issue rather than a
> statistical one. Having established a range of indifference, you will need
> to compute the confidence interval for the treatment effect in your data.
> To support a claim of non-inferiority, the confidence interval must fall
> within the specified range of clinical indifference.
>
> You may find the following book helpful. It provides a comprehensive
> treatment of the subject in understandable terms.
>
> Stefan Wellek (2010). Testing statistical hypotheses of equivalence, 2nd
> Edition. Chapman and Hall.
>
> Best,
>
> Stephen Brand
>
> www.StatisticsDoc.com
>
> [snip, previous]