Posted by
Maguin, Eugene on
Feb 23, 2011; 9:32pm
URL: http://spssx-discussion.165.s1.nabble.com/appropriate-statistical-method-needed-tp3397707p3397756.html
FUB,
Here is an initial idea. The allowable pH range is known. If the pH values
in a person's data series remain within the range, score=1; otherwise,
score=0. Test Tx proportion greater than control proportion by one sided
test of proportions. Is this adequate for a phase II drug trial. No idea but
I'd bet not.
I think you might be much better served by finding a list-serv that focuses
on medical statistics because this sort of question is quite odd, I think,
for social science people, which is who I think is mostly on this list. But,
perhaps, I'm wrong.
Gene Maguin
-----Original Message-----
From: SPSSX(r) Discussion [mailto:
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drfg2008
Sent: Wednesday, February 23, 2011 4:04 PM
To:
[hidden email]
Subject: appropriate statistical method needed
For a Phase II drug trial an appropriate statistical method is sought.
The following Background:
In a research on the acidity of gastric juice during cardiopulmonary bypass
surgery a drug has been used and tested for efficacy.
During the entire operation the acidity of gastric juice should remain in a
non-hazardous area. Neither the pH value should be too high nor too low.
Maximum and minimum limits are given.
The sample was relatively small. Patients were randomly assigned to two
groups of 20 persons each group. One group did not receive the drug, the
other group did. The 40 operations lasted different lengths. Every second a
probe of the stomach pH was measured. There are therefore 40 time series of
different lengths of pH values.
Question: It is to be examined whether the pH values could be stabilized due
to the drug for the entire duration of the operation within the safe area.
The effectiveness compared with the control group without drug is to be
demonstrated.
Which procedure, which method would be in question here?
-----
FUB
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